FCAG launches expanded evaluation for embryo implantation failure

By AI, Created 8:11 PM UTC, May 29, 2026, /AGP/ – Fertility Center & Applied Genetics of Florida has launched a new diagnostic program for patients whose high-quality or euploid embryo transfers did not result in pregnancy. The Sarasota- and Bonita Springs-based clinic says the evaluation is now available and is designed to identify uterine, inflammatory, microbiome and timing issues that could affect the next transfer.

Why it matters: - Failed embryo transfer after a good-quality or euploid embryo can leave patients without clear next steps. - FCAG’s new program is designed to find treatable causes before another frozen embryo transfer, rather than repeating the same protocol. - The clinic is targeting a selected group of patients with prior implantation failure, where more testing may change treatment decisions.

What happened: - Fertility Center & Applied Genetics of Florida launched an Expanded Evaluation for Embryo Implantation Failure on May 31, 2026. - The private fertility and reproductive genetics clinic operates in Sarasota and Bonita Springs, Florida. - Julio E. Pabon, M.D., F.A.C.O.G., serves as Medical and Laboratory Director. - The evaluation is available now at both Florida locations. - Patients outside Florida can coordinate parts of the evaluation before an in-person visit. - More information is available in the company’s announcement.

The details: - The program centers on a mock hormone replacement cycle that mirrors the next frozen embryo transfer protocol without exposing an embryo to risk. - The mock cycle is used to study endometrial timing and biology under transfer-like conditions. - The evaluation includes an Igenomix TRIO endometrial biopsy. - ERA, or Endometrial Receptivity Analysis, checks whether the window of implantation is receptive, pre-receptive or post-receptive. - EMMA, or Endometrial Microbiome Metagenomic Analysis, evaluates the uterine bacterial environment, including Lactobacillus dominance. - ALICE, or Analysis of Infectious Chronic Endometritis, screens for pathogenic bacteria linked to chronic endometrial inflammation. - The program also includes ReceptivaDx biopsy during the same mock cycle. - ReceptivaDx evaluates BCL6 overexpression and inflammatory markers. - Elevated BCL6 has been associated with progesterone resistance, occult endometriosis, blocked fallopian tubes and decreased implantation. - Office diagnostic hysteroscopy is used to examine the uterine cavity directly. - Hysteroscopy can identify polyps, subtle adhesions, small cavity-distorting fibroids, surface inflammation and adenomyosis pockets. - Intrauterine platelet-rich plasma, or PRP, is used selectively for patients with persistently thin endometrium or repeated failed transfers despite otherwise normal findings. - PRP is prepared from the patient’s own blood and contains concentrated growth factors. - Current evidence suggests potential benefit from PRP, with further trials ongoing. - FCAG says implantation depends on embryo competence, endometrial preparation, uterine cavity health and a balanced hormonal and microbiologic environment. - The clinic says true recurrent implantation failure is uncommon. - For many patients, reviewing embryo quality, transfer timing and uterine preparation is enough.

Between the lines: - The launch reflects a more individualized approach to IVF after failed transfers, especially when embryo genetics are not the obvious problem. - FCAG is also signaling caution: the clinic says endometrial receptivity testing is still an evolving area and not every patient needs every test. - Dr. Pabon said the goal is to avoid repeating the same cycle without learning why the last one failed. - The clinic says each test is included only when it answers a specific clinical question. - FCAG has built its reputation around genetic testing and single-embryo transfer, so the new program extends that evidence-first model into post-failure evaluation. - The clinic says more than 98% of its IVF treatments now include genetic testing of embryos. - FCAG was the first clinic in Florida to offer single euploid blastocyst transfers for both fresh and frozen-thawed cycles.

What’s next: - FCAG will tailor the evaluation to each patient’s history, prior protocols and clinical picture. - The clinic expects some patients to adjust their transfer protocol based on mock-cycle findings. - Out-of-state and international patients can begin coordination before traveling to Florida. - Patients seeking consultation can contact FCAG’s Sarasota or Bonita Springs offices.

The bottom line: - FCAG is betting that a targeted, test-by-test review of the uterine environment can improve decision-making after failed euploid embryo transfers.